Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I

Document 2026-12654 is a Final Rule published by the Department of Justice in the Federal Register on June 24, 2026. The Administrator of the Drug Enforcement Administration is issuing this notice of intent to publish a temporary order to schedule O-desmethyltramadol (other names: O-DSMT; desmetramadol; 3-[(1R,2R)-2- [(dimethylamino)methyl]-1-hydroxycyclohexyl]phenol), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, in schedule I of the Controlled Substances Act. When it is issued, the temporary scheduling order will impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle O-DSMT. View the original at https://www.federalregister.gov/documents/2026/06/24/2026-12654/schedules-of-controlled-substances-temporary-placement-of-o-desmethyltramadol-in-schedule-i.

No. Document 2026-12654 is not classified as economically significant under Executive Order 12866. Economically significant rules require OIRA review and are estimated to have impacts of $100 million or more per year.