Specific Listing for 1-boc-4-piperidone, a Currently Controlled List I Chemical

Document 2025-19349 is a Final Rule published by the Department of Justice in the Federal Register on October 2, 2025, with an effective date of October 2, 2025. The Drug Enforcement Administration (DEA) is establishing a specific listing and DEA Chemical Code Number for tert-butyl 4- oxopiperidine-1-carboxylate (also known as 1-boc-4-piperidone; and CAS Number: 79099-07-3) and its salts as a list I chemical under the Controlled Substances Act (CSA). Although 1-boc-4-piperidone is not specifically listed as a list I chemical of the CSA with its own unique Chemical Code Number, it has been regulated as a list I chemical in the United States as a carbamate of 4-piperidone, a list I chemical, since May 12, 2023. Therefore, DEA is simply amending the list of list I chemicals in its regulations to separately include 1-boc-4-piperidone. View the original at https://www.federalregister.gov/documents/2025/10/02/2025-19349/specific-listing-for-1-boc-4-piperidone-a-currently-controlled-list-i-chemical.

No. Document 2025-19349 is not classified as economically significant under Executive Order 12866. Economically significant rules require OIRA review and are estimated to have impacts of $100 million or more per year.