Controlled Substances Ordering System (CSOS) Modernization

Document 2025-19325 is a Final Rule published by the Department of Justice in the Federal Register on October 2, 2025, with an effective date of November 3, 2025. This rule is amending the Drug Enforcement Administration's (DEA) regulations to conform to the Controlled Substances Ordering System (CSOS) modernization effort by requiring all CSOS enrollment applications and supporting materials to be submitted through the Diversion Control Division secure online portal. These amendments improve the enrollment process by aligning it with DEA's current requirements for other online form submissions. The online submission of enrollment applications and supporting material through the secure online portal increases the efficiency of the enrollment, modification, and revocation processes, and ensures DEA's receipt of accurate documentation in a more timely and organized manner. View the original at https://www.federalregister.gov/documents/2025/10/02/2025-19325/controlled-substances-ordering-system-csos-modernization.

No. Document 2025-19325 is not classified as economically significant under Executive Order 12866. Economically significant rules require OIRA review and are estimated to have impacts of $100 million or more per year.